Henrik Clausen

GLYCOSCIENCE SPEAKERS

Henrik Clausen

University of Copenhagen

DDS (1981) and DSc (1990). Worked in the glycobiology field for 30+ years focusing on structure, biosynthesis and genetic regulation of complex carbohydrates. Studied with professor Sen-Itiroh Hakomori in Seattle (1983-90) on blood group related carbohydrates, glycosyltransferases and genes. Started a glycobiology research group at the Faculty of Health and Medical Sciences, University of Copenhagen in 1990. Since 2012 head of Copenhagen Center for Glycomics. Past member of scientific advisory boards and consultant for Neose Technologies and ZymeQuest, founder of GlycoZym, GO-therapeutics, and GlycoDisplay, and national representative for International Glycoconjugate Organization. Research focus is primarily protein glycosylation - isolated, cloned, and expressed many of the human glycosyltransferases involved in mucin-type O-glycosylation and O-mannosylation. Our interests are broad and include basic understanding of genetic regulation, and biosynthesis of protein glycosylation, immunity to glycans and glycoproteins, consequences of deficiencies in glycosylation in diseases, and biomedical applications. We developed strategies to isolate and characterize O-glycoproteomes of cells – the SimpleCell strategy. We broadly apply genetic glycoengineering of mammalian cells for de/reconstruction of glycosylation capacities and recently developed a cell-based glycan array. We design optimal platform cells for production of recombinant therapeutics and pursue unique glycodesigns for improved glycoprotein therapeutics.