Dr. Nicola Maria Nathalie Ternette
Head of Antigen Discovery/Immunopeptidomics
University of Oxford
Henry Wellcome Building for Molecular Physiology
Old Road Campus
Oxford, OX3 7BN, UK
Dr. Nicola Ternette trained in Physics and Biochemistry at the Universities of Bonn, Greifswald and Bochum in Germany. Her graduation first in her class in Biochemistry in 2003 was recognized with a price by the Ruth and Gert Massenberg-Foundation. She further pursued her post-graduate studies in developing and evaluating DNA vaccines for Respiratory Syncytial Virus (RSV) at the Institute for Molecular and Medical Virology in Bochum in the laboratory of Professor Klaus Überla. Following her PhD, she continued her research on viral infection using mass spectrometric methods supported by post-doctoral fellowships by the German Academic Exchange Service (DAAD) and the German Research Society (DFG) at the University of Oxford in the Target Discovery Institute Mass Spectrometry Laboratory led by Professor Benedikt Kessler. She specialized in sequencing of HLA-associated peptidomes using nanoflow ultra-performance liquid chromatography tandem mass spectrometry (LC-MS) with the focus on identification of viral antigens for the development of T cell vaccines. In 2015, she set up a specialized mass spectrometry facility at The Jenner Institute in collaboration with the Target Discovery Institute Mass Spectrometry Laboratory for the identification of HLA-ligands by LC-MS. Currently, the Immunopeptidomics facility has two state-of-the-art mass spectrometry platforms and her group has expanded their expertise to deep sequencing of immunopeptidomes in multiple pathogen infection models, analysis of the antigenic landscape of solid tumours and haematological cancers and characterisation of antigens involved in autoimmune diseases.